| Citation: |
LI Feng, GUO Li, CAI Liqun. Impacts of Yiqi Yangyin Tongluo Recipe combinedwith calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(15): 40-44. DOI: 10.7619/jcmp.20231206
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To explore effect of Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome.
A total of 120 patients with diabetes nephropathy (Qi and Yin deficiency and blood stasis syndrome) were selected as research objects. They were randomly divided into control group (60 cases) and observation group (60 cases). The control group was treated with calcium dobesilate, and the observation group was treated with Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate. Fasting blood glucose (FBG) and 2 h postprandial blood glucose (2 h PGB) levels of two groups were compared before and after treatment. The levels of total cholesterol (TC) and triglyceride (TG) before and after treatment were measured by automatic biochemical analyzer. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were measured by immunoturbidimetry. The 24 h urine was collected before and after treatment, and the 24 h urine protein (24 h Upro) level was detected by picric acid method. Serum levels of vascular endothelial growth factor (VEGF), endothelin (ET-1) and nitric oxide (NO) were detected by ELISA kit.
The total effective rate of treatment in the observation group was obviously higher than that in the control group (91.67% versus 70.00%, P < 0.05). After treatment, FBG, 2 h PGB, TC, TG, BUN, Scr, 24 h Upro levels in both groups decreased obviously compared to those before treatment, and the observation group decreased more obviously than those in the control group (P < 0.05); after treatment, the levels of creatinine clearance (Ccr) was obviously increased compared to those before treatment, and the observation group increased more obviously than those in the control group (P < 0.05). The level of hemorheology indexes in both groups decreased after treatment, and the observation group decreased more obviously than that in control group (P < 0.05).The level of ET-1 in two groups after treatment was lower than that before treatment, and the observation group decreased more obviously than that in control group (P < 0.05). The levels of VEGF and NO in two groups were higher after treatment than before treatment, and the observation group increased more obviously than those in the control group (P < 0.05).
Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate can effectively regulate glucose and lipid metabolism, improve renal function, hemorheology and vascular endothelial function in the treatment of diabetes nephropathy.
| [1] |
COLE J B, FLOREZ J C. Genetics of diabetes mellitus and diabetes complications[J]. Nat Rev Nephrol, 2020, 16(7): 377-390. doi: 10.1038/s41581-020-0278-5
|
| [2] |
BONNER R, ALBAJRAMI O, HUDSPETH J, et al. Diabetic kidney disease[J]. Prim Care, 2020, 47(4): 645-659. doi: 10.1016/j.pop.2020.08.004
|
| [3] |
A/L B VASANTH RAO V R, TAN S H, CANDASAMY M, et al. Diabetic nephropathy: an update on pathogenesis and drug development[J]. Diabetes Metab Syndr, 2019, 13(1): 754-762. doi: 10.1016/j.dsx.2018.11.054
|
| [4] |
QIN L L, QIN W J, WANG J F, et al. Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate[J]. Exp Ther Med, 2017, 14(5): 5012-5016.
|
| [5] |
李金鑫, 齐记, 倪珊珊. 养阴通络汤治疗糖尿病肾病Ⅳ期临床疗效及对患者非杓型血压的影响[J]. 现代中西医结合杂志, 2023, 32(5): 657-661. doi: 10.3969/j.issn.1008-8849.2023.05.014
|
| [6] |
SELBY N M, TAAL M W. An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines[J]. Diabetes Obes Metab, 2020, 22(Suppl 1): 3-15.
|
| [7] |
梁茂新, 高天舒. 《中药新药临床研究指导原则》脏腑诸证考察与分析[J]. 中国中医基础医学杂志, 2008, 14(5): 330-331, 342. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC200805004.htm
|
| [8] |
LEE J Y, YANG J W, HAN B G, et al. Adiponectin for the treatment of diabetic nephropathy[J]. Korean J Intern Med, 2019, 34(3): 480-491. doi: 10.3904/kjim.2019.109
|
| [9] |
KEATING S T, VAN DIEPEN J A, RIKSEN N P, et al. Epigenetics in diabetic nephropathy, immunity and metabolism[J]. Diabetologia, 2018, 61(1): 6-20. doi: 10.1007/s00125-017-4490-1
|
| [10] |
UMANATH K, LEWIS J B. Update on diabetic nephropathy: core curriculum 2018[J]. Am J Kidney Dis, 2018, 71(6): 884-895. doi: 10.1053/j.ajkd.2017.10.026
|
| [11] |
ZHOU Y J, QI C J, LI S, et al. Diabetic nephropathy can be treated with calcium dobesilate by alleviating the chronic inflammatory state and improving endothelial cell function[J]. Cell Physiol Biochem, 2018, 51(3): 1119-1133. doi: 10.1159/000495491
|
| [12] |
HAKIMIZADEH E, ZAMANIAN M Y, DAMANKHORSHID M, et al. Calcium dobesilate protects against d-galactose-induced hepatic and renal dysfunction, oxidative stress, and pathological damage[J]. Fundamemntal Clinical Pharma, 2022, 36(4): 721-730. doi: 10.1111/fcp.12766
|
| [13] |
LI G J, AI B C, ZHANG W H, et al. Efficacy and safety of astragalus injection combined with Western medicine in the treatment of early diabetic nephropathy[J]. Medicine, 2021, 100(12): e25096. doi: 10.1097/MD.0000000000025096
|
| [14] |
张家刚. 益气养阴通络汤联合前列地尔治疗糖尿病肾病临床疗效观察[J]. 实用糖尿病杂志, 2020, 16(6): 72-73. https://www.cnki.com.cn/Article/CJFDTOTAL-LNSY202006077.htm
|
| [15] |
李康玲, 陈光影, 韦志杰. 益气养阴通络方联合替米沙坦治疗早期2型糖尿病肾病临床疗效观察[J]. 黑龙江医药, 2020, 33(3): 587-589. https://www.cnki.com.cn/Article/CJFDTOTAL-HJYY202003047.htm
|
| [16] |
王庆美, 张林, 孔素梅, 等. 羟苯磺酸钙联合前列地尔对早期糖尿病肾病患者血管内皮功能的影响[J]. 海南医学院学报, 2019, 25(9): 674-678, 682. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201909010.htm
|
| [17] |
苏敏. 降糖精颗粒联合西药治疗早期糖尿病肾病的效果评价[J]. 实用临床医药杂志, 2018, 22(21): 115-117. doi: 10.7619/jcmp.201821036
|
| [18] |
袁博寒, 陈洪宇, 郑峰. 益气养阴通络方联合祛风湿法治疗糖尿病肾病疗效观察[J]. 中国中西医结合肾病杂志, 2020, 21(12): 1051-1054. https://www.cnki.com.cn/Article/CJFDTOTAL-JXSB202012008.htm
|
| [19] |
唐晨拳, 周恩超. 益气养阴通络方治疗糖尿病肾病Ⅲ~Ⅳ期气阴两虚血瘀证患者的疗效观察[J]. 实用临床医药杂志, 2021, 25(5): 79-82. doi: 10.7619/jcmp.20201463
|
| [20] |
刘迎迎, 郭兆安, 周太荣, 等. 益气养阴通络汤治疗糖尿病肾病G3aA2期气阴两虚血瘀证的临床疗效与安全性评价[J]. 中华中医药杂志, 2021, 36(2): 1180-1184. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202102151.htm
|
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