Objective To explore effect of Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome.
Methods A total of 120 patients with diabetes nephropathy (Qi and Yin deficiency and blood stasis syndrome) were selected as research objects. They were randomly divided into control group (60 cases) and observation group (60 cases). The control group was treated with calcium dobesilate, and the observation group was treated with Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate. Fasting blood glucose (FBG) and 2 h postprandial blood glucose (2 h PGB) levels of two groups were compared before and after treatment. The levels of total cholesterol (TC) and triglyceride (TG) before and after treatment were measured by automatic biochemical analyzer. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were measured by immunoturbidimetry. The 24 h urine was collected before and after treatment, and the 24 h urine protein (24 h Upro) level was detected by picric acid method. Serum levels of vascular endothelial growth factor (VEGF), endothelin (ET-1) and nitric oxide (NO) were detected by ELISA kit.
Results The total effective rate of treatment in the observation group was obviously higher than that in the control group (91.67% versus 70.00%, P < 0.05). After treatment, FBG, 2 h PGB, TC, TG, BUN, Scr, 24 h Upro levels in both groups decreased obviously compared to those before treatment, and the observation group decreased more obviously than those in the control group (P < 0.05); after treatment, the levels of creatinine clearance (Ccr) was obviously increased compared to those before treatment, and the observation group increased more obviously than those in the control group (P < 0.05). The level of hemorheology indexes in both groups decreased after treatment, and the observation group decreased more obviously than that in control group (P < 0.05).The level of ET-1 in two groups after treatment was lower than that before treatment, and the observation group decreased more obviously than that in control group (P < 0.05). The levels of VEGF and NO in two groups were higher after treatment than before treatment, and the observation group increased more obviously than those in the control group (P < 0.05).
Conclusion Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate can effectively regulate glucose and lipid metabolism, improve renal function, hemorheology and vascular endothelial function in the treatment of diabetes nephropathy.
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