Advance Search
LI Feng, GUO Li, CAI Liqun. Impacts of Yiqi Yangyin Tongluo Recipe combinedwith calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(15): 40-44. DOI: 10.7619/jcmp.20231206
Citation: LI Feng, GUO Li, CAI Liqun. Impacts of Yiqi Yangyin Tongluo Recipe combinedwith calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(15): 40-44. DOI: 10.7619/jcmp.20231206
shu

Impacts of Yiqi Yangyin Tongluo Recipe combinedwith calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome

  • 1.

    Department of Endocrinology, Heilongjiang Academy of Chinese Medicine, Harbin, Heilongjiang, 150040

  • 2.

    Department of Laboratory Medicine, Heilongjiang Academy of Chinese Medicine, Harbin, Heilongjiang, 150040

More Information
  • Received Date: April 16, 2023
  • Revised Date: June 11, 2023
  • Available Online: September 03, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To explore effect of Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate in patients with diabetes nephropathy differentiated as Qi and Yin deficiency and blood stasis syndrome.

    Methods 

    A total of 120 patients with diabetes nephropathy (Qi and Yin deficiency and blood stasis syndrome) were selected as research objects. They were randomly divided into control group (60 cases) and observation group (60 cases). The control group was treated with calcium dobesilate, and the observation group was treated with Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate. Fasting blood glucose (FBG) and 2 h postprandial blood glucose (2 h PGB) levels of two groups were compared before and after treatment. The levels of total cholesterol (TC) and triglyceride (TG) before and after treatment were measured by automatic biochemical analyzer. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were measured by immunoturbidimetry. The 24 h urine was collected before and after treatment, and the 24 h urine protein (24 h Upro) level was detected by picric acid method. Serum levels of vascular endothelial growth factor (VEGF), endothelin (ET-1) and nitric oxide (NO) were detected by ELISA kit.

    Results 

    The total effective rate of treatment in the observation group was obviously higher than that in the control group (91.67% versus 70.00%, P < 0.05). After treatment, FBG, 2 h PGB, TC, TG, BUN, Scr, 24 h Upro levels in both groups decreased obviously compared to those before treatment, and the observation group decreased more obviously than those in the control group (P < 0.05); after treatment, the levels of creatinine clearance (Ccr) was obviously increased compared to those before treatment, and the observation group increased more obviously than those in the control group (P < 0.05). The level of hemorheology indexes in both groups decreased after treatment, and the observation group decreased more obviously than that in control group (P < 0.05).The level of ET-1 in two groups after treatment was lower than that before treatment, and the observation group decreased more obviously than that in control group (P < 0.05). The levels of VEGF and NO in two groups were higher after treatment than before treatment, and the observation group increased more obviously than those in the control group (P < 0.05).

    Conclusion 

    Yiqi Yangyin Tongluo Recipe combined with calcium dobesilate can effectively regulate glucose and lipid metabolism, improve renal function, hemorheology and vascular endothelial function in the treatment of diabetes nephropathy.

    • FullText(HTML)
    • References (20)
  • [1]
    COLE J B, FLOREZ J C. Genetics of diabetes mellitus and diabetes complications[J]. Nat Rev Nephrol, 2020, 16(7): 377-390. doi: 10.1038/s41581-020-0278-5
    [2]
    BONNER R, ALBAJRAMI O, HUDSPETH J, et al. Diabetic kidney disease[J]. Prim Care, 2020, 47(4): 645-659. doi: 10.1016/j.pop.2020.08.004
    [3]
    A/L B VASANTH RAO V R, TAN S H, CANDASAMY M, et al. Diabetic nephropathy: an update on pathogenesis and drug development[J]. Diabetes Metab Syndr, 2019, 13(1): 754-762. doi: 10.1016/j.dsx.2018.11.054
    [4]
    QIN L L, QIN W J, WANG J F, et al. Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate[J]. Exp Ther Med, 2017, 14(5): 5012-5016.
    [5]
    李金鑫, 齐记, 倪珊珊. 养阴通络汤治疗糖尿病肾病Ⅳ期临床疗效及对患者非杓型血压的影响[J]. 现代中西医结合杂志, 2023, 32(5): 657-661. doi: 10.3969/j.issn.1008-8849.2023.05.014
    [6]
    SELBY N M, TAAL M W. An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines[J]. Diabetes Obes Metab, 2020, 22(Suppl 1): 3-15.
    [7]
    梁茂新, 高天舒. 《中药新药临床研究指导原则》脏腑诸证考察与分析[J]. 中国中医基础医学杂志, 2008, 14(5): 330-331, 342. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC200805004.htm
    [8]
    LEE J Y, YANG J W, HAN B G, et al. Adiponectin for the treatment of diabetic nephropathy[J]. Korean J Intern Med, 2019, 34(3): 480-491. doi: 10.3904/kjim.2019.109
    [9]
    KEATING S T, VAN DIEPEN J A, RIKSEN N P, et al. Epigenetics in diabetic nephropathy, immunity and metabolism[J]. Diabetologia, 2018, 61(1): 6-20. doi: 10.1007/s00125-017-4490-1
    [10]
    UMANATH K, LEWIS J B. Update on diabetic nephropathy: core curriculum 2018[J]. Am J Kidney Dis, 2018, 71(6): 884-895. doi: 10.1053/j.ajkd.2017.10.026
    [11]
    ZHOU Y J, QI C J, LI S, et al. Diabetic nephropathy can be treated with calcium dobesilate by alleviating the chronic inflammatory state and improving endothelial cell function[J]. Cell Physiol Biochem, 2018, 51(3): 1119-1133. doi: 10.1159/000495491
    [12]
    HAKIMIZADEH E, ZAMANIAN M Y, DAMANKHORSHID M, et al. Calcium dobesilate protects against d-galactose-induced hepatic and renal dysfunction, oxidative stress, and pathological damage[J]. Fundamemntal Clinical Pharma, 2022, 36(4): 721-730. doi: 10.1111/fcp.12766
    [13]
    LI G J, AI B C, ZHANG W H, et al. Efficacy and safety of astragalus injection combined with Western medicine in the treatment of early diabetic nephropathy[J]. Medicine, 2021, 100(12): e25096. doi: 10.1097/MD.0000000000025096
    [14]
    张家刚. 益气养阴通络汤联合前列地尔治疗糖尿病肾病临床疗效观察[J]. 实用糖尿病杂志, 2020, 16(6): 72-73. https://www.cnki.com.cn/Article/CJFDTOTAL-LNSY202006077.htm
    [15]
    李康玲, 陈光影, 韦志杰. 益气养阴通络方联合替米沙坦治疗早期2型糖尿病肾病临床疗效观察[J]. 黑龙江医药, 2020, 33(3): 587-589. https://www.cnki.com.cn/Article/CJFDTOTAL-HJYY202003047.htm
    [16]
    王庆美, 张林, 孔素梅, 等. 羟苯磺酸钙联合前列地尔对早期糖尿病肾病患者血管内皮功能的影响[J]. 海南医学院学报, 2019, 25(9): 674-678, 682. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY201909010.htm
    [17]
    苏敏. 降糖精颗粒联合西药治疗早期糖尿病肾病的效果评价[J]. 实用临床医药杂志, 2018, 22(21): 115-117. doi: 10.7619/jcmp.201821036
    [18]
    袁博寒, 陈洪宇, 郑峰. 益气养阴通络方联合祛风湿法治疗糖尿病肾病疗效观察[J]. 中国中西医结合肾病杂志, 2020, 21(12): 1051-1054. https://www.cnki.com.cn/Article/CJFDTOTAL-JXSB202012008.htm
    [19]
    唐晨拳, 周恩超. 益气养阴通络方治疗糖尿病肾病Ⅲ~Ⅳ期气阴两虚血瘀证患者的疗效观察[J]. 实用临床医药杂志, 2021, 25(5): 79-82. doi: 10.7619/jcmp.20201463
    [20]
    刘迎迎, 郭兆安, 周太荣, 等. 益气养阴通络汤治疗糖尿病肾病G3aA2期气阴两虚血瘀证的临床疗效与安全性评价[J]. 中华中医药杂志, 2021, 36(2): 1180-1184. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202102151.htm
    • Related Articles

  • Related Articles

    [1]SUN Yanting, WU Wei, WU Sisi, XUE Rongliang. Effects of sevoflurane on renal function and endothelial nitric oxide synthase of rats with renal ischemia reperfusion injury[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 104-108. DOI: 10.7619/jcmp.20211999
    [2]LUO Liya, LIU Cuiqing, GENG Lijie, LIU Shanshan, ZHANG Wei, ZHANG Shuai. Effect of different doses of atorvastatin on vascular endothelial function in elderly patients with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2021, 25(16): 103-106, 111. DOI: 10.7619/jcmp.20211235
    [3]ZHANG Hui, GUO Yan. Effect of norepinephrine combined with esmolol on myocardial function and lactate clearance rate in patients with septic shock[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 10-13, 16. DOI: 10.7619/jcmp.201917003
    [4]YE Lei, WEN Li. Effect of rosuvastatin on vascular endothelial function, cardiac function and hemodynamics in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2018, (1): 18-20. DOI: 10.7619/jcmp.201801006
    [5]MA Qiang, CUI Guoxiong. Effect of atorvastatin combined with trimetazidine on the cardiac function, inflammatory factors and vascular endothelial function in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2016, (23): 5-8. DOI: 10.7619/jcmp.201623002
    [6]WU Dexu, ZHU Jun, CAI Wenyuan, WANG Guangyan, TENG Mingzi. Effects of salvianolate on oxidative stress and vascular endothelial function in patients with acute myocardial infarction by treatment of PCI[J]. Journal of Clinical Medicine in Practice, 2016, (19): 16-19. DOI: 10.7619/jcmp.201619005
    [7]ZHANG Hao, SHI Wei, LI Zepu, JIANG Hao. Influence of rosuvastatin on hemorheology and endothelial function of patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2016, (17): 15-17,24. DOI: 10.7619/jcmp.201617005
    [8]YAN Yin, LIU Duo, LI Cheng, FAN Wenhui. Analysis of vascular endothelial function, Hcy level and prognosis in patients with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2016, (9): 10-13. DOI: 10.7619/jcmp.201609003
    [9]ZHAO Qingzhen, LIU Gang, LIU Chao, LIU Kunshen. The effect of anti-depression treatment on endothelial function of the patients with coronary heart disease and depression[J]. Journal of Clinical Medicine in Practice, 2014, (7): 103-105. DOI: 10.7619/jcmp.201407034
    [10]MA Jun. Influence of atorvastatin on endothelial function in patients with atherosclerosis and hypertension[J]. Journal of Clinical Medicine in Practice, 2014, (3): 63-65. DOI: 10.7619/jcmp.201403020

  • Cited by

    Periodical cited type(5)

    1. 杨斌，夏克明，韩飞. 骨科创伤性失血患者输血不良反应调查及危险因素分析. 中国当代医药. 2024(10): 131-134 .
    2. 张媚琰，顾屏，李婷婷. 输血不良反应发生的现状分析及影响因素调查. 中国医学创新. 2024(31): 175-178 .
    3. 王胜蓝，贵明飞，华敏玉，李鹏，卓创近，刘钟梅，杨霞，黄霞，何涛. 急性输血不良反应发生时间调查及分析. 临床输血与检验. 2023(01): 33-37 .
    4. 陆国健，吴文强，廖阳东，王晓刚，陆春兰. 基于凝血指标、血栓弹力图构建急性再生障碍性贫血患者输血不良反应发生风险预测模型及其验证. 东南大学学报(医学版). 2023(05): 673-680 .
    5. 赖志辉. 探讨预防性用药对降低输血不良反应发生率所产生的影响. 北方药学. 2023(09): 146-148 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (142) PDF downloads (7) Cited by(5)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return