Clinical application of shear wave elastography parameters in early assessment of neoadjuvant pathological response in patients with breast cancer

XIANG Santing; WANG Wenping; LEI Fan; LI Qian; YU Feihong

doi:10.7619/jcmp.20231371

Journal of Clinical Medicine in Practice > 2023 > 27(16): 11-15. > DOI: 10.7619/jcmp.20231371

XIANG Santing, WANG Wenping, LEI Fan, LI Qian, YU Feihong. Clinical application of shear wave elastography parameters in early assessment of neoadjuvant pathological response in patients with breast cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(16): 11-15. DOI: 10.7619/jcmp.20231371

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Clinical application of shear wave elastography parameters in early assessment of neoadjuvant pathological response in patients with breast cancer

1.
Department of Ultrasound Diagnosis, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 211199
2.
Department of Ultrasound Diagnosis, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029

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Received Date: April 26, 2023
Revised Date: June 15, 2023
Available Online: September 05, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the value of shear wave elastography (SWE) parameters in early prediction of pathological response to neoadjuvant chemotherapy (NAC) in invasive breast cancer.
Methods
A total of 96 patients with invasive breast cancer who received full course NAC treatment were included. Routine two-dimensional ultrasound and SWE were performed in patients before NAC and after the second cycle to obtain change rate of maximum lesion diameter at the end of the second cycle of NAC (ΔD), change rate of maximum elastic value at the end of the second cycle of NAC (ΔE_max) and change rate of average elastic value at the end of secondcycle of NAC(ΔE_mean). All patients were treated surgically and were divided into pathological complete response (PCR) group(n=33) and non-PCR group(n=63) according to Miller&Payne's pathological grade. The clinicopathological data and elastic quantitative parameters of the two groups were compared. Receiver operating characteristic (ROC) curves were plotted to analyze and compare their predictive efficacy.
Results
Multivariate Logistic regression analysis showed that human epidermal growth factor receptor 2 (HER2) and ΔE_max were independent predictors of NAC pathological response (OR=6.25, P < 0.05; OR=3.72, P < 0.05). The prediction efficiency of the combined model of HER2 and ΔE_max was optimal, with the area under the curve (AUC) of 0.87 (95%CI, 0.79 to 0.94).
Conclusion
The change rates of SWE elastic parameters have predictive value in the early stage of NAC for breast cancer. The combined HER2 and ΔE_max model can improve the diagnostic efficiency in predicting the pathological response of NAC.
- two-dimensional ultrasound,
- shear wave elastography,
- neoadjuvant chemotherapy,
- invasive breast cancer,
- predictive model

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References (15)

References

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Clinical application of shear wave elastography parameters in early assessment of neoadjuvant pathological response in patients with breast cancer