Efficacy of probiotics combined with montelukast in treatment of children with Mycoplasma pneumoniae pneumonia complicated with myocardial injury

Objective To observe the therapeutic effect of probiotics combined with montelukast in children with Mycoplasma pneumoniae pneumonia (MPP) complicated with myocardial injury.

Methods A total of 102 children with MPP and myocardial injury were selected as the study objects, and were randomly divided into control group and observation group, with 51 cases in each group. The control group was treated with montelukast, and the observation group was treated with probiotics based on the control group. The clinical efficacy, symptom resolution time, hospital stay, myocardial injury index, inflammatory cytokines, intestinal flora level and incidence of adverse reactions were compared between the two groups.

Results The total effective rate of the observation group was 92.16%, which was significantly higher than 76.47% of the control group (P < 0.05). The disappearance time of symptoms of fever, cough, shortness of breath, chest tightness and chest pain and hospital stay in the observation group were significantly shorter than those in the control group (P < 0.05). After treatment, the levels of cardiac troponin T (cTnT), B-type natriuretic peptide (BNP), myoglobin (Mb) and cardiac fatty acid binding protein (H-FABP) in the observation group were significantly lower than those in the control group(P < 0.05); the levels of interleukin-1 receptor 1(IL-1R1), gamma-interferon (γ-IFN) and high mobility group protein 1(HMGB1) in the observation group were significantly lower than those inthe control group (P < 0.05); the number of Bifidobacteria, Lactobacillus acidophilus, Enterococcus faecalis and Bacillus cereus in the observation group were significantly higher than the control group, while the number of Escherichia coli and Salmonella were significantly lower than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).

Conclusion Probiotics combined with montelukast have good efficacy in MPP children with myocardial injury, which can shorten the time of symptom resolution and hospital stay, improve the indexes of myocardial injury in children, inhibit the level of inflammatory cytokines, adjust the structure of intestinal flora disorder, and have good safety.