Effect of early time-restricted feeding on vitamin D and glycolipid metabolism in overweight/obese patients with polycystic ovary syndrome

TANG Lu; HU Liping; LI Qingjiao; CAI Hua

doi:10.7619/jcmp.20232294

Journal of Clinical Medicine in Practice > 2023 > 27(18): 127-132. > DOI: 10.7619/jcmp.20232294

TANG Lu, HU Liping, LI Qingjiao, CAI Hua. Effect of early time-restricted feeding on vitamin D and glycolipid metabolism in overweight/obese patients with polycystic ovary syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(18): 127-132. DOI: 10.7619/jcmp.20232294

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Effect of early time-restricted feeding on vitamin D and glycolipid metabolism in overweight/obese patients with polycystic ovary syndrome

Department of Clinical Nutrition, the First Hospital Affiliated to Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, 410005

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Received Date: July 19, 2023
Revised Date: September 11, 2023
Available Online: October 08, 2023

Graphical Abstract

Abstract

Abstract

Objective
To explore the early time-restricted feeding (e-TRF) on serum vitamin D level and glycolipid metabolism in overweight/obese patients with polycystic ovary syndrome (PCOS).
Methods
A total of 35 overweight/obese patients with PCOS were publicly recruited for treatment of 4-week e-TRF dietary intervention in the body quality management clinic of authors' hospital. Before and after intervention, the human body composition analysis and blood sampling tests (serum vitamin D level and biochemical indicators related to glucose and lipid metabolism) were conducted, and changes in various indicators were compared.
Results
After 4 weeks of e-TRF intervention, the level of vitamin D in 35 patients increased significantly, and the ratios of cases with vitamin D deficiency or insufficiency decreased significantly (P < 0.01). In the indicators of glucose and lipid metabolism, the levels of glycated hemoglobin, fasting blood glucose, fasting insulin, insulin resistance index, total cholesterol, triglycerides and low-density lipoprotein cholesterol decreased significantly after intervention when compared to those before intervention, while the level of high-density lipoprotein cholesterol increased significantly when compared to that intervention before (P < 0.05). After intervention, the vitamin D level was significantly negatively correlated with body weight, body mass index, hip circumference, fasting insulin, insulin resistance index and triglycerides (r=-0.451, -0.352, -0.424, -0.543, -0.491, -0.394, P < 0.05).
Conclusion
The e-TRF can increase vitamin D level in overweight/obese patients with PCOS in a short period of time (4 weeks), reduce body mass, and improve glucose and lipid metabolism indicators.
- early time-restricted feeding,
- overweight,
- obese,
- polycystic ovary syndrome,
- vitamin D,
- glycolipid metabolism

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References (34)

References

[1]	中国医师协会内分泌代谢科医师分会. 多囊卵巢综合征诊治内分泌专家共识[J]. 中华内分泌代谢杂志, 2018, 34(1): 1-7.
[2]	ESCOBAR-MORREALE H F. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment[J]. Nat Rev Endocrinol, 2018, 14(5): 270-284. doi: 10.1038/nrendo.2018.24
[3]	WU Q, GAO J, BAI D X, et al. The prevalence of polycystic ovarian syndrome in Chinese women: a meta-analysis[J]. Ann Palliat Med, 2021, 10(1): 74-87. doi: 10.21037/apm-20-1893
[4]	MU Y, CHENG D, YIN T L, et al. Vitamin D and polycystic ovary syndrome: a narrative review[J]. Reprod Sci, 2021, 28(8): 2110-2117. doi: 10.1007/s43032-020-00369-2
[5]	TEEDE H J, TAY C T, JOHAM A E. Polycystic ovary syndrome: an intrinsic risk factor for diabetes compounded by obesity[J]. Fertil Steril, 2021, 115(6): 1449-1450. doi: 10.1016/j.fertnstert.2021.03.024
[6]	LUMME J, SEBERT S, PESONEN P, et al. Vitamin D levels in women with polycystic ovary syndrome: a population-based study[J]. Nutrients, 2019, 11(11): 2831. doi: 10.3390/nu11112831
[7]	江波, 白文佩, 郁琦, 等. 生酮饮食干预多囊卵巢综合征中国专家共识(2018年版)[J]. 实用临床医药杂志, 2019, 23(1): 1-4. doi: 10.7619/jcmp.201901001
[8]	MOHAN A, HAIDER R, FAKHOR H, et al. Vitamin D and polycystic ovary syndrome (PCOS): a review[J]. Ann Med Surg, 2023, 85(7): 3506-3511. doi: 10.1097/MS9.0000000000000879
[9]	MANOOGIAN E N C, CHOW L S, TAUB P R, et al. Time-restricted eating for the prevention and management of metabolic diseases[J]. Endocr Rev, 2022, 43(2): 405-436. doi: 10.1210/endrev/bnab027
[10]	XIE Z B, SUN Y N, YE Y Q, et al. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity[J]. Nat Commun, 2022, 13(1): 1003. doi: 10.1038/s41467-022-28662-5
[11]	ROTTERDAM ESHRE/ASRM-SPONSORED PCOS CONSENSUS WORKSHOP GROUP. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J]. Fertil Steril, 2004, 81(1): 19-25. doi: 10.1016/j.fertnstert.2003.10.004
[12]	MIFFLIN M D, ST JEOR S T, HILL L A, et al. A new predictive equation for resting energy expenditure in healthy individuals[J]. Am J Clin Nutr, 1990, 51(2): 241-247. doi: 10.1093/ajcn/51.2.241
[13]	中国营养学会. 中国居民膳食指南(2022)[M]. 北京: 人民卫生出版社, 2022: 345-346.
[14]	TEEDE H J, MISSO M L, COSTELLO M F, et al. Erratum. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome[J]. Hum Reprod, 2019, 34(2): 388. doi: 10.1093/humrep/dey363
[15]	夏维波, 章振林, 林华, 等. 维生素D及其类似物临床应用共识[J]. 中华骨质疏松和骨矿盐疾病杂志, 2018, 11(1): 1-19. https://www.cnki.com.cn/Article/CJFDTOTAL-GUSS201801001.htm
[16]	HOLICK M F, BINKLEY N C, BISCHOFF-FERRARI H A, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab, 2011, 96(7): 1911-1930. doi: 10.1210/jc.2011-0385
[17]	FLINT A, RABEN A, BLUNDELL J E, et al. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies[J]. Int J Obes Relat Metab Disord, 2000, 24(1): 38-48. doi: 10.1038/sj.ijo.0801083
[18]	SUTTON E F, BEYL R, EARLY K S, et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes[J]. Cell Metab, 2018, 27(6): 1212-1221, e3. doi: 10.1016/j.cmet.2018.04.010
[19]	KRUL-POEL Y H, SNACKEY C, LOUWERS Y, et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review[J]. Eur J Endocrinol, 2013, 169(6): 853-865. doi: 10.1530/EJE-13-0617
[20]	VRANIC L, MIKOLAŠEVIC I, MILIC S. Vitamin D deficiency: consequence or cause of obesity[J]. Medicina, 2019, 55(9): 541. doi: 10.3390/medicina55090541
[21]	李健, 白文佩, 江波, 等. 生酮饮食对超重/肥胖多囊卵巢综合征患者维生素D及糖脂代谢的影响[J]. 实用临床医药杂志, 2022, 26(4): 14-17, 32. doi: 10.7619/jcmp.20220496
[22]	SZYMCZAK-PAJOR I, SLIWINSKA A. Analysis of association between vitamin D deficiency and insulin resistance[J]. Nutrients, 2019, 11(4): 794. doi: 10.3390/nu11040794
[23]	LI C Z, XING C, ZHANG J Q, et al. Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women withanovulatory polycystic ovary syndrome[J]. J Transl Med, 2021, 19(1): 148. doi: 10.1186/s12967-021-02817-2
[24]	郑思岚. 限时饮食对超重/肥胖多囊卵巢综合征患者减重的随机对照干预研究[D]. 厦门: 厦门大学, 2020.
[25]	ANTON S D, MOEHL K, DONAHOO W T, et al. Flipping the metabolic switch: understanding and applying the health benefits of fasting[J]. Obesity, 2018, 26(2): 254-268. doi: 10.1002/oby.22065
[26]	RAVUSSIN E, BEYL R A, POGGIOGALLE E, et al. Early time-restricted feeding reduces appetite and increases fat oxidation but does not affect energy expenditure in humans[J]. Obesity, 2019, 27(8): 1244-1254. doi: 10.1002/oby.22518
[27]	ANTONI R, JOHNSTON K L, COLLINS A L, et al. Effects of intermittent fasting on glucose and lipid metabolism[J]. Proc Nutr Soc, 2017, 76(3): 361-368. doi: 10.1017/S0029665116002986
[28]	汪俊宇, 张安仁. 肠道菌群在间歇性禁食治疗肥胖中的作用研究[J]. 中国全科医学, 2019, 22(27): 3308-3311. doi: 10.12114/j.issn.1007-9572.2019.00.452
[29]	SEIMON R V, ROEKENES J A, ZIBELLINI J, et al. Do intermittent diets provide physiological benefits over continuous diets for weight loss A systematic review of clinical trials[J]. Mol Cell Endocrinol, 2015, 418(Pt 2): 153-172.
[30]	HE C L, LIN Z M, ROBB S W, et al. Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis[J]. Nutrients, 2015, 7(6): 4555-4577. doi: 10.3390/nu7064555
[31]	卫小静, 郭欢, 赵阳, 等. 维生素D对多囊卵巢综合征患者糖脂代谢指标的影响[J]. 中国妇幼保健, 2022, 37(20): 3692-3695. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202220003.htm
[32]	MARTENS C R, ROSSMAN M J, MAZZO M R, et al. Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults[J]. Geroscience, 2020, 42(2): 667-686. doi: 10.1007/s11357-020-00156-6
[33]	GABEL K, HODDY K K, VARADY K A. Safety of 8-h time restricted feeding in adults with obesity[J]. Appl Physiol Nutr Metab, 2019, 44(1): 107-109. doi: 10.1139/apnm-2018-0389
[34]	LOWE D A, WU N, ROHDIN-BIBBY L, et al. Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT randomized clinical trial[J]. JAMA Intern Med, 2020, 180(11): 1491-1499.

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Effect of early time-restricted feeding on vitamin D and glycolipid metabolism in overweight/obese patients with polycystic ovary syndrome

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