Efficacy and prognostic factors of ultrasound-guided microwave ablation for benign thyroid nodules

GUO Weihong; HUANG Xiaoyun; LIU Shuyan; XU Juping; LI Yongfeng; TIAN Yanfei; SHEN Junjie

doi:10.7619/jcmp.20233139

Journal of Clinical Medicine in Practice > 2024 > 28(16): 5-9. > DOI: 10.7619/jcmp.20233139

GUO Weihong, HUANG Xiaoyun, LIU Shuyan, XU Juping, LI Yongfeng, TIAN Yanfei, SHEN Junjie. Efficacy and prognostic factors of ultrasound-guided microwave ablation for benign thyroid nodules[J]. Journal of Clinical Medicine in Practice, 2024, 28(16): 5-9. DOI: 10.7619/jcmp.20233139

Citation:

PDF (818 KB)

Efficacy and prognostic factors of ultrasound-guided microwave ablation for benign thyroid nodules

1.
Department of Ultrasound, the First Affiliated Hospital of Henan Polytechnic University/Jiaozuo Second People's Hospital, Jiaozuo, Henan, 454000
2.
Department of Endocrinology, the First Affiliated Hospital of Henan Polytechnic University/Jiaozuo Second People's Hospital, Jiaozuo, Henan, 454000
3.
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Henan Polytechnic University/Jiaozuo Second People's Hospital, Jiaozuo, Henan, 454000

More Information

Received Date: October 06, 2023
Revised Date: February 17, 2024

Graphical Abstract

Abstract

Abstract

Objective
To compare the efficacy of ultrasound-guided microwave ablation versus thyroidectomy in the treatment of benign thyroid nodules (BTN) and to explore the influencing factors of prognosis.
Methods
A total of 282 BTN patients were enrolled and divided into ablation group (treated with ultrasound-guided microwave ablation, n=172) and resection group (treated with thyroidectomy, n=110) based on treatment methods. Perioperative indicators and thyroid function indices before and after surgery were compared between the two groups. Patients were followed up for 1 year and divided into good prognosis group [volume reduction rate (VRR)≥80%, n=210] and a poor prognosis group (VRR < 80%, n=72) based on the VRR. Factors influencing the prognosis of BTN patients were analyzed.
Results
The ablation group had shorter operative time and hospital stay, less intraoperative blood loss, and lower postoperative Visual Analogue Scale (VAS) scores compared to the resection group (P < 0.05). One month after surgery, serum thyrotropin (TSH) levels were higher, while free triiodothyronine (FT3) and free thyroxine (FT4) levels were lower than preoperative levels in both groups, however, TSH level was lower, and FT3 and FT4 levels were higher in the ablation group compared to the resection group (P < 0.05). Univariate analysis showed that preoperative TSH levels, the proportion of solid nodules, and the proportion of nodules in the risk zone were lower, while preoperative FT4 levels were higher in the good prognosis group compared to the poor prognosis group (P < 0.05). Binary Logistic regression analysis revealed that nodule type, nodule location, preoperative TSH, and preoperative FT4 were all influencing factors for the prognosis of BTN patients (P < 0.05).
Conclusion
Compared to thyroidectomy, ultrasound-guided microwave ablation for BTN offers advantages such as less intraoperative blood loss, milder postoperative pain, shorter operative time and hospital stay, and less damage to thyroid function. Preoperative TSH and FT4 levels, nodule type, and nodule location are closely related to the prognosis of BTN patients and should be given attention in clinical practice.
- benign thyroid nodules,
- ultrasound guidance,
- microwave ablation,
- thyroidectomy,
- prognosis,
- influencing factors

FullText(HTML)

References (18)

References

[1]	JIN H, LIN W D, LU L G, et al. Conventional thyroidectomy vs thyroid thermal ablation on postoperative quality of life and satisfaction for patients with benign thyroid nodules[J]. Eur J Endocrinol, 2021, 184(1): 131-141.
[2]	刘家斌, 杨云梅, 侯宁. 夏枯草颗粒对桥本甲状腺炎合并甲状腺结节手术患者围术期促炎与抗炎状态的影响研究[J]. 海军医学杂志, 2021, 42(5): 614-616.
[3]	邓佳琳, 王小平. 超声引导下微波消融治疗甲状腺良性结节的临床效果及安全性评估[J]. 现代肿瘤医学, 2022, 30(21): 3882-3886.
[4]	周平盛, 刘晟, 王能, 等. 超声引导下微波消融治疗肝细胞癌术后肿瘤复发及其危险因素分析[J]. 介入放射学杂志, 2022, 31(12): 1174-1178. doi: 10.3969/j.issn.1008-794X.2022.12.008
[5]	倪文婧, 褚晓秋, 陆晨雅, 等. 超声引导下微波消融治疗12例原发性甲状旁腺功能亢进症的疗效及安全性[J]. 中华内科杂志, 2021, 60(10): 904-907. doi: 10.3760/cma.j.cn112138-20201111-00935
[6]	霍胜男, 魏莹, 彭丽丽, 等. 超声引导下微波消融治疗异位继发性甲状旁腺功能亢进症[J]. 中国介入影像与治疗学, 2021, 18(10): 592-595.
[7]	沙晓溪, 饶程义, 袁艺, 等. 微血管珊瑚成像技术在甲状腺结节微波消融随访中的应用[J]. 中国超声医学杂志, 2021, 37(1): 11-14. doi: 10.3969/j.issn.1002-0101.2021.01.004
[8]	邱云, 杨玫, 薛红红. TACE联合超声引导下微波消融治疗特殊部位原发性肝癌患者疗效研究[J]. 实用肝脏病杂志, 2022, 25(3): 419-422. doi: 10.3969/j.issn.1672-5069.2022.03.029
[9]	PAPARODIS R D, KARVOUNIS E, BANTOUNA D, et al. Large, slowly growing, benign thyroid nodules frequently coexist with synchronous thyroid cancers[J]. J Clin Endocrinol Metab, 2022, 107(8): e3474-e3478.
[10]	李保启, 王佳佳, 王金萍, 等. 超声引导下微波消融治疗甲状腺良性结节34例近期评估[J]. 安徽医药, 2022, 26(1): 66-69. doi: 10.3969/j.issn.1009-6469.2022.01.015
[11]	唐婉晴, 唐秀云, 张晓娟, 等. 超声引导下微波消融治疗甲状腺乳头状癌颈部转移性淋巴结的临床价值[J]. 临床超声医学杂志, 2022, 24(10): 780-783.
[12]	RADMILOVIC-RADJENOVIC M, RADJENOVIC D, RADJENOVIC B. Finite element analysis of the effect of microwave ablation on the liver, lung, kidney, and bone malignant tissues[J]. Europhys Lett, 2021, 136(2): 28001.
[13]	PRASAD R, AL-ABCHA A, ELSHAFIE A, et al. Meta-analysis of lung ultrasound-guided therapy in chronic heart failure[J]. J Am Coll Cardiol, 2021, 77(18): 722.
[14]	KIM Y J, BAHETI A, HUBER T C. Radiofrequency ablation of solid benign thyroid nodules[J]. Tech Vasc Interv Radiol, 2022, 25(2): 100819.
[15]	王瑜. 小切口腺叶切除术治疗甲状腺癌的手术效果[J]. 中国现代普通外科进展, 2021, 24(10): 808-810.
[16]	武晓娜. 甲状腺腺叶切除术治疗甲状腺结节的临床疗效及其甲状腺相关激素变化研究[J]. 山西医药杂志, 2021, 50(4): 581-583. doi: 10.3969/j.issn.0253-9926.2021.04.018
[17]	黄玉慧, 宋宇, 付尧, 等. 甲状腺囊实性结节微波消融方案及术中囊内出血的影响因素[J]. 中国医学影像学杂志, 2022, 30(9): 927-932, 940. doi: 10.3969/j.issn.1005-5185.2022.09.010
[18]	徐元兵, 潘代, 陶溢潮, 等. 血清TSH与超声造影联合评分法对TI-RADS4类甲状腺微小结节良恶性的诊断价值[J]. 现代肿瘤医学, 2021, 29(14): 2428-2432. doi: 10.3969/j.issn.1672-4992.2021.14.008

[1]	TAO Rui, HAN Wenchao, Ding Tianxiang, FAN Chongshan. Circular RNA_0032131 regulates the proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting microRNA-145-5p[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 53-57, 62. DOI: 10.7619/jcmp.20240212
[2]	QIU Shu, LU Hongmei, ZHOU Jie. Expression and clinicopathological significance of ultra-conserved RNA-339 in cervical squamous cell carcinoma[J]. Journal of Clinical Medicine in Practice, 2023, 27(11): 32-37,42. DOI: 10.7619/jcmp.20230723
[3]	CHEN Yanrong, LIU Yan, WANG Shan, ZHANG Jing. Expression characteristics and detection value of histamine, soluble myeloid cell trigger receptor-1, microribonuclease-145 and high-sensitivity C-reactive protein in patients with chronic obstructive pulmonary disease and coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 1-5. DOI: 10.7619/jcmp.20223161
[4]	HU Zhipeng, YE Zhi, ZHANG Qingxin. Establishment of a prediction model of lymph node metastasis in patients with non-small cell lung cancer at high altitude areas based on energy spectrum CT parameters and clinicopathological factors[J]. Journal of Clinical Medicine in Practice, 2022, 26(18): 6-10. DOI: 10.7619/jcmp.20220739
[5]	LIU Peifa, HOU Wenyu, JIAN Yanbing. Expression levels of microRNA-485-3p and Xklp2 target protein in breast cancer tissues and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 29-34. DOI: 10.7619/jcmp.20212629
[6]	CHEN Jingzhi, MA Lili, FENG Yanyu. Expressions of circulating tumor cells, microribonucleic acid 1246, carbohydrate antigen 153 in breast cancer patients and their relationships with different clinicopathological features and prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 17-20, 25. DOI: 10.7619/jcmp.20211886
[7]	ZHANG Nana, SHEN Bin, CHEN Xi, LIANG Wenlong, ZHANG Jianguo. Research progress of microRNAs in breast cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(4): 106-110, 115. DOI: 10.7619/jcmp.20201506
[8]	YAN Yun, GUO Yulian, WANG Chenghai. Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
[9]	DENG Hui, LI Xinyu, WU Yandan, WANG Chenghai. Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance[J]. Journal of Clinical Medicine in Practice, 2019, 23(9): 5-8. DOI: 10.7619/jcmp.201909002
[10]	WANG Haigang, XIE Hongmei, HAN Xue, ZHANG Lixian, ZHAO Wenzeng. Expression of uH2B in primary adenocarcinoma of the colon and its relationship with clinicopathological parameters[J]. Journal of Clinical Medicine in Practice, 2017, (9): 99-102. DOI: 10.7619/jcmp.201709025

Cited By

Get Citation

PDF

XML

Article views (118) PDF downloads (19)

Turn off MathJax

Article Contents

Abstract

References

Efficacy and prognostic factors of ultrasound-guided microwave ablation for benign thyroid nodules

Abstract

References

Related Articles

Catalog

Efficacy and prognostic factors of ultrasound-guided microwave ablation for benign thyroid nodules

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content