A multicenter study on pioneering symptoms of gastrointestinal symptom cluster in 463 gastric cancer patients with chemotherapy

XIA Chao; DUAN Peibei; YANG Liping; FEI Chaonan; ZHANG Ziyan; ZOU Yanling; LI Yi; YANG Ling

doi:10.7619/jcmp.20243904

Journal of Clinical Medicine in Practice > 2025 > 29(2): 124-128, 137. > DOI: 10.7619/jcmp.20243904

XIA Chao, DUAN Peibei, YANG Liping, FEI Chaonan, ZHANG Ziyan, ZOU Yanling, LI Yi, YANG Ling. A multicenter study on pioneering symptoms of gastrointestinal symptom cluster in 463 gastric cancer patients with chemotherapy[J]. Journal of Clinical Medicine in Practice, 2025, 29(2): 124-128, 137. DOI: 10.7619/jcmp.20243904

Citation:

PDF (1060 KB)

A multicenter study on pioneering symptoms of gastrointestinal symptom cluster in 463 gastric cancer patients with chemotherapy

1.
Department of Oncology, Jiangsu Provincial Hospital of Chinese Medicine, Nanjing, Jiangsu, 210029
2.
Department of Nursing, Jiangsu Provincial Hospital of Chinese Medicine, Nanjing, Jiangsu, 210029
3.
College of Nursing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023

More Information

Received Date: August 29, 2024
Revised Date: October 27, 2024

Graphical Abstract

Abstract

Abstract

Objective
To explore the pioneering symptoms of the gastrointestinal symptom cluster and their influencing factors in gastric cancer patients with chemotherapy.
Methods
Based on the hospital's management system for scientific research data, 463 gastric cancer patients with chemotherapy were surveyed through multicenter collaboration by the corresponding module of the MD Anderson Symptom Inventory (MDASI), the Chinese Medicine Constitution Classification and Identification Standard, and the Chinese Medicine SyndromeIdentification Standard for Gastric Cancer. IBM SPSS Statistic 22.0 and IBM SPSS Modeler 18.0 were used for data analysis.
Results
The first occurrence of dry mouth in the gastrointestinal symptom cluster of gastric cancer patients with chemotherapy was (22.99±10.70) hours after chemotherapy. The support, confidence, and lift for the association between dry mouth and decreased appetite were 62.2%, 94.8% and 1.52, respectively; for dry mouth and nausea, the numerical values were 62.2%, 89.6% and 1.44; for dry mouth and vomiting, the numerical values were 62.2%, 79.5% and 1.28. The results of one-way ANOVA and multivariate linear regression analysis showed that alcohol consumption, syndrome of stomach heat injuring yin, and phlegm-dampness constitution were independent influencing factors for dry mouth in gastric cancer patients with chemotherapy (P < 0.05).
Conclusion
Dry mouth, as a pioneering symptom of the gastrointestinal symptom cluster, is of great significance in clinical assessment and management. Improved assessment of dry mouth can provide a basis for the construction of subsequent risk prediction model, the formulation of targeted interventions, and the enhancement of symptom management efficiency.
- chemotherapy,
- gastric cancer,
- symptom cluster,
- pioneering symptoms,
- dry mouth

FullText(HTML)

References (33)

References

[1]	AJANI J A, D'AMICO T A, BENTREM D J, et al. Gastric cancer, version 2. 2022, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2022, 20(2): 167-192. doi: 10.6004/jnccn.2022.0008
[2]	ZHANG Q Q, QIAN Y, YIN Y. Comparison of S-1-based vs. capecitabine-based adjuvant chemotherapy for patients with gastric cancer: a systematic review and meta-analysis[J]. Eur J Clin Pharmacol, 2021, 77(12): 1791-1804. doi: 10.1007/s00228-021-03187-w
[3]	PIECHOTTA V, ADAMS A, HAQUE M, et al. Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis[J]. Cochrane Database Syst Rev, 2021, 11(11): CD012775.
[4]	陈鑫容, 袁星竹, 杨婕, 等. 胃癌患者症状群及机制的研究进展[J]. 现代临床护理, 2022, 21(12): 76-81.
[5]	王潇. 胃癌术后化疗患者症状群及其亚组识别的纵向研究[D]. 南京: 南京中医药大学, 2019.
[6]	翟莹莹, 杨姮, 周文琴. 癌症患者症状群概述及管理措施研究现状[J]. 护理学报, 2019, 26(1): 32-35.
[7]	吴贤群, 尚彬, 周燕, 等. 基于网络分析的维持性血液透析患者透析期间核心症状研究[J]. 实用临床医药杂志, 2023, 27(15): 56-61, 67.
[8]	吴圣贤, 王成祥. 临床研究样本含量估算[M]. 北京: 人民卫生出版社, 2008: 70-80.
[9]	CLEELAND C S, MENDOZA T R, WANG X S, et al. Assessing symptom distress in cancer patients: the M. D. Anderson Symptom Inventory[J]. Cancer, 2000, 89(7): 1634-1646. doi: 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V
[10]	WANG X S, WANG Y, GUO H, et al. Chinese version of the M. D. Anderson Symptom Inventory: validation and application of symptom measurement in cancer patients[J]. Cancer, 2004, 101(8): 1890-1901. doi: 10.1002/cncr.20448
[11]	CHEN Y J, LI X T, CHEN T, et al. Postoperative rehabilitation management self-efficacy and its relationship with symptoms in the patients with lung cancer: a latent profile analysis[J]. Asia Pac J Oncol Nurs, 2024, 11(9): 100554. doi: 10.1016/j.apjon.2024.100554
[12]	中华中医药学会. 中医体质分类与判定[M]. 北京: 中国中医药出版社, 2009: 1-53.
[13]	张浩彬, 周伟珠. IBM SPSS Modeler 18. 0数据挖掘权威指南[M]. 北京: 人民邮电出版社, 2020: 21-53.
[14]	夏超, 段培蓓, 杨玲, 等. 166例胃癌术后化疗患者症状群内前哨症状的调查[J]. 护理学报, 2021, 28(8): 44-49.
[15]	WEI L Z, LV F, LUO C F, et al. Study on sentinel symptoms and influencing factors of postoperative chemotherapy in patients with gastric cancer[J]. Eur J Oncol Nurs, 2023, 64: 102318. doi: 10.1016/j.ejon.2023.102318
[16]	马景双, 王爱平. 肺癌术后化疗患者症状群及前哨症状的调查[J]. 护理学报, 2021, 28(12): 33-37.
[17]	杨晨. 食管癌放疗期患者症状群及前哨症状的研究[D]. 石家庄: 河北医科大学, 2023.
[18]	居晓迪. 化疗期肺癌患者症状群及其前哨症状的纵向研究[D]. 合肥: 安徽医科大学, 2023.
[19]	郑翔, 李琰华. 口干的全科诊疗思路[J]. 中华全科医师杂志, 2023, 22(4): 443-448.
[20]	杜海霞, 危常磊, 张慧, 等. 124例萎缩性舌炎相关因素分析[J]. 上海口腔医学, 2020, 29(4): 423-426.
[21]	杨宝峰. 药理学: 改编教学版[M]. 北京: 人民卫生出版社, 2018: 65-305.
[22]	ENG S H, JAARSMA T, LUPÓN J, et al. Thirst and factors associated with frequent thirst in patients with heart failure in Spain[J]. Heart Lung, 2021, 50(1): 86-91. doi: 10.1016/j.hrtlng.2020.08.002
[23]	LEE C W, LIU S T, CHENG Y J, et al. Prevalence, risk factors, and optimized management of moderate-to-severe thirst in the post-anesthesia care unit[J]. Sci Rep, 2020, 10(1): 16183. doi: 10.1038/s41598-020-73235-5
[24]	刘鑫, 谢金芹, 张婷, 等. 非药物干预对缓解术后患者口渴强度效果的网状Meta分析[J]. 护士进修杂志, 2022, 37(19): 1779-1785.
[25]	王正国创伤医学基金会围术期加速康复护理联盟. 成人术后口渴症状评估与管理的专家共识[J]. 军事护理, 2022, 39(12): 1-4.
[26]	姚立群, 柯昌荣, 亓建羽, 等. 1990—2019年我国与世界不同社会人口学指数地区归因于饮酒导致的疾病负担比较分析[J]. 中国卫生经济, 2022, 41(5): 64-67.
[27]	吴静远, 许博文, 李杰. 基于温病胃阴学说论治胃热伤阴型胃癌[J]. 长春中医药大学学报, 2020, 36(6): 1100-1103.
[28]	迟文成, 耿雪, 姜家康, 等. 中西医结合治疗肿瘤化疗后不良反应的研究进展[J]. 实用临床医药杂志, 2022, 26(8): 126-130, 136.
[29]	张东伟, 祝永福, 王春花, 等. 中医辨证分型与替吉奥治疗进展期胃癌的临床疗效及预后分析[J]. 世界中西医结合杂志, 2021, 16(8): 1486-1490, 1550.
[30]	姜利, 彭小莉, 童辉, 等. 住院患者口渴非药物干预的证据总结[J]. 中国临床护理, 2022, 14(7): 441-445.
[31]	常小兰, 刘思兰, 奚冰, 等. 薄荷醇穴位敷贴防治消化道肿瘤患者围术期口渴疗效观察[J]. 海南医学, 2020, 31(4): 442-445.
[32]	张佩, 余明红, 何丽波, 等. 胃癌化疗患者中医体质分型与化疗期间感染和免疫功能及胃肠道菌群的关系[J]. 中华医院感染学杂志, 2023, 33(3): 386-390.
[33]	刘兴, 王琦, 李炜, 等. 痰湿体质知识图谱构建研究初探[J]. 北京中医药大学学报, 2022, 45(9): 949-955.

[1]	WANG Jingjing, WU Su, CAI Guilan, ZHEN Yong. Construction and application of a risk prediction model for lower limb deep vein thrombosis in patients with aneurysmal subarachnoid hemorrhage[J]. Journal of Clinical Medicine in Practice, 2024, 28(19): 95-99, 104. DOI: 10.7619/jcmp.20241629
[2]	ZHU Huayuan, ZHANG Yajuan, SUN Qian, HUANG Yan, YANG Bingyin. Establishment of a Nomogram prediction model for chronic constipation patients based on body position exercise training[J]. Journal of Clinical Medicine in Practice, 2024, 28(17): 109-113. DOI: 10.7619/jcmp.20241488
[3]	LIU Haijia, CHEN Ming, LI Yanzhen. Analysis in risk factors of postoperative recurrence of patients with refractory epilepsy and establishment of a risk prediction model[J]. Journal of Clinical Medicine in Practice, 2024, 28(8): 7-11. DOI: 10.7619/jcmp.20240080
[4]	ZHANG Jiangnan, LI Ronghua, ZHOU Hongmei, XU Minyi, CAI Liangyu. Establishment of a predictive model for the risk of deep vein thrombosis after orthopedic surgery in the lower extremities and its verification[J]. Journal of Clinical Medicine in Practice, 2023, 27(23): 73-78. DOI: 10.7619/jcmp.20231971
[5]	SONG Feng, FANG Canjun, HU Jing, CHEN Yi. Risk factors of preoperative deep venous thrombosis in young and middle-aged patients with hip fracture and construction of a Nomogram predictive model[J]. Journal of Clinical Medicine in Practice, 2023, 27(12): 32-37. DOI: 10.7619/jcmp.20230579
[6]	REN Yuanyuan, DING Fu, XU Zhihui, FU Rongjuan. Research status of fall risk prediction models for inpatients[J]. Journal of Clinical Medicine in Practice, 2023, 27(8): 144-148. DOI: 10.7619/jcmp.20230036
[7]	ZHANG Wei, LI Yang. Value of color Doppler ultrasound combined with coagulation indexes detection in predicting deep venous thrombosis of lower limbs after fracture[J]. Journal of Clinical Medicine in Practice, 2022, 26(24): 20-23. DOI: 10.7619/jcmp.20222678
[8]	SHAO Chao, GAO Wencan, ZHANG Jun, SHEN Bin, XU Jianwei, YIN Kai. Establishment of prediction model of deep venous thrombosis formation of lower extremity after general surgery[J]. Journal of Clinical Medicine in Practice, 2022, 26(22): 12-15, 19. DOI: 10.7619/jcmp.20221634
[9]	ZANG Peng, LI Jinxia, LI Ji, ZHANG Huizhi, GU Yan. Experimental study of Huangqi Guizhi Wuwu Decoctionin prevention and treatment of rats model with deep venous thrombosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(13): 12-17. DOI: 10.7619/jcmp.20220385
[10]	DONG Yanping, WANG Jiemin, WANG Yujin, REN Yali, DONG Yucheng, YONG Yanjun, SU Xuandi, WANG Jixiang, SU Nan, WANG Fuli, XIA Duosheng. Construction and evaluation of Nomogram prediction model for postoperative recurrence of pterygium[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 52-56. DOI: 10.7619/jcmp.20214610

Cited By

Cited by

Periodical cited type(6)

1.	黄晨岚. 25羟维生素D、超敏c反应蛋白、估计肾小球滤过率与脑萎缩相关性的临床研究. 黑龙江医药. 2024(01): 44-47 .
2.	桂千，侯晓夏，徐勤荣，冯红选，吴冠会，卢艳丽，程庆璋. 脑微出血与非关键部位脑梗死患者认知功能的相关性. 实用临床医药杂志. 2023(13): 43-47+52 . 本站查看
3.	蹇秋枫，徐荣华，姚倩，周媛媛. 中国老年脑卒中患者认知障碍患病率和影响因素的Meta分析. 中国全科医学. 2023(32): 4070-4079+4088 .
4.	李梦洁，肖佳男，刘文娟，练芮含，张丽秀. 外周血1, 25-(OH)_2D_3、神经元特异性烯醇化酶、神经胶质纤维酸性蛋白在小儿复杂性惊厥中的表达意义. 中国儿童保健杂志. 2023(11): 1254-1259 .
5.	张丽. 脑梗死后认知功能损害与神经功能恢复及生活质量的相关性研究. 临床研究. 2022(08): 77-80 .
6.	雷霄明，薛孟周，夏彬，李晶，郭平平. 血清25-羟维生素D和脂联素与脑白质损伤患者认知功能的相关性研究. 实用临床医药杂志. 2022(19): 33-37 . 本站查看

Other cited types(1)

Get Citation

PDF

XML

Article views (49) PDF downloads (5) Cited by(7)

Turn off MathJax

Article Contents

Abstract

References

A multicenter study on pioneering symptoms of gastrointestinal symptom cluster in 463 gastric cancer patients with chemotherapy

Abstract

References

Related Articles

Cited by

Periodical cited type(6)

Other cited types(1)

Catalog

A multicenter study on pioneering symptoms of gastrointestinal symptom cluster in 463 gastric cancer patients with chemotherapy

Abstract

References

Related Articles

Cited by

Periodical cited type(6)

Other cited types(1)

Catalog

Export File

Citation

Format

Content