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LI Fengxia, WANG Yanshuo, SHI Yanxiang, LIU Linlin, FENG Yuhuan. Effect of vitamin E combined with metformin in infertility patients with polycystic ovary syndrome[J]. Journal of Clinical Medicine in Practice, 2022, 26(14): 97-100, 104. DOI: 10.7619/jcmp.20220640
Citation: LI Fengxia, WANG Yanshuo, SHI Yanxiang, LIU Linlin, FENG Yuhuan. Effect of vitamin E combined with metformin in infertility patients with polycystic ovary syndrome[J]. Journal of Clinical Medicine in Practice, 2022, 26(14): 97-100, 104. DOI: 10.7619/jcmp.20220640
shu

Effect of vitamin E combined with metformin in infertility patients with polycystic ovary syndrome

  • 1.

    Department of Gynecology, Xingtai Maternal and Child Health Hospital in Hebei Province, Xingtai, Hebei, 054000

  • 2.

    Department of Obstetrics and Gynecology, Shenzhou Hospital of Hebei Province, Hengshui, Hebei, 053800

  • 3.

    Reproductive Medicine Center, Tangshan Maternal and Child Health Hospital of Hebei Province, Tangshan, Hebei, 063000

More Information
  • Received Date: February 28, 2022
  • Available Online: July 13, 2022
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the effect of vitamin E combined with metformin in infertility patients with polycystic ovary syndrome (PCOS).

    Methods 

    A total of 120 PCOS infertile patients were selected as research objects, and randomly divided into control group (60 cases) and combined group (60 cases). Both groups received basic treatment, the control group was additionally treated with metformin, and the combined group was additionally treated with vitamin E. Insulin-like growth factor-1 (IGF-1), monocyte chemoattractant protein-1 (MCP-1), sex hormone, oxidative stress level, endometrial thickness and ovarian volume were observed before and after treatment in two groups. The total effective rate, ovulation rate and pregnancy rate were compared between the two groups.

    Results 

    After treatment, IGF-1, MCP-1, luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH and testosterone (T) in two groups were significantly lower than before treatment, and those in the combined group were significantly lower than those in the control group (P < 0.05). Superoxide dismutase (SOD) and total antioxidant state (TAS) in the combined group were significantly higher than those in the control group, and serum total oxidation state (TOS) in the combined group was significantly lower than that in the control group (P < 0.05). Endometrial thickness was thicker, and ovarian volume in the combined group was significantly smaller than those in the control group (P < 0.05). The total effective rate in the combined group was significantly higher than that in the control group (P < 0.05). Ovulation rate in the combined group was 80.00%, which was significantly higher than 50.00% in the control group (P < 0.05). The pregnancy rate in the combined group was 50.00%, which was significantly higher than 13.33% in the control group (P < 0.05).

    Conclusion 

    Vitamin E combined with metformin has a good effect in infertility patients with PCOS, which can reduce the levels of IGF-1 and MCP-1, improve the levels of sex hormones and oxidative stress, and promote the recovery of patients.

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    • References (20)
  • [1]
    党晓丽. 炔雌醇环丙孕酮和二甲双胍联合治疗多囊卵巢综合征合并不孕症的效果及对激素水平的影响评价[J]. 贵州医药, 2019, 43(6): 915-916. doi: 10.3969/j.issn.1000-744X.2019.06.027
    [2]
    贾小林, 李娜. 腹腔镜下卵巢打孔术配合克罗米芬、人绒毛膜促性腺激素对多囊卵巢综合征所致不孕症的临床效果[J]. 实用临床医药杂志, 2019, 23(7): 102-105. doi: 10.7619/jcmp.201907027
    [3]
    ABRAHAM A, KATTOOR A J, SALDEEN T, et al. Vitamin E and its anticancer effects[J]. Crit Rev Food Sci Nutr, 2019, 59(17): 2831-2838. doi: 10.1080/10408398.2018.1474169
    [4]
    安旭琢, 李晓莉. 二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征患者对IGFB P-1、IL-18、抗氧化指标的影响[J]. 医学临床研究, 2022, 39(1): 150-152. doi: 10.3969/j.issn.1671-7171.2022.01.044
    [5]
    GRANADA M L. Biochemical following-up of treated acromegaly. Limitations of the current determinations of IGF-1 and perspective[J]. Minerva Endocrinol, 2019, 44(2): 143-158.
    [6]
    陈丹丹, 张慧. 二甲双胍联合来曲唑治疗克罗米芬耐药PCOS不孕症的临床疗效[J]. 安徽医学, 2021, 42(8): 916-920. doi: 10.3969/j.issn.1000-0399.2021.08.022
    [7]
    中华医学会妇产科学分会内分泌学组及指南专家组. 多囊卵巢综合征中国诊疗指南[J]. 中华妇产科杂志, 2018, 53(1): 2-6. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ201810010.htm
    [8]
    鲍旭东, 徐杨, 傅荣. 炔雌醇环丙孕酮联合二甲双胍对多囊卵巢综合征不孕症患者激素水平的影响[J]. 实用临床医药杂志, 2018, 22(1): 104-106, 110. doi: 10.7619/jcmp.201801032
    [9]
    ORTIZ-FLORES A E, LUQUE-RAMÍREZ M, ESCOBAR-MORREALE H F. Polycystic ovary syndrome in adult women[J]. Med Clin (Barc), 2019, 152(11): 450-457. doi: 10.1016/j.medcli.2018.11.019
    [10]
    姜晓琳, 刘静, 张阳, 等. 苍附导痰汤加二甲双胍联合穴位埋线对肥胖型多囊卵巢综合征不孕症患者免疫功能及肠道菌群的影响[J]. 临床误诊误治, 2020, 33(8): 51-56. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ202008013.htm
    [11]
    李盈, 赖金醛, 邓岳红. 二甲双胍+炔雌醇环丙孕酮治疗多囊卵巢综合征不孕症的效果及对患者排卵率和妊娠率的影响评价[J]. 中国性科学, 2019, 28(4): 61-64. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201904019.htm
    [12]
    黄伟燕. 二甲双胍联合氯米芬对多囊卵巢综合征并不孕症患者内皮功能、内分泌指标和临床结局的影响[J]. 中国基层医药, 2019, 26(21): 2643-2648. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS202114025.htm
    [13]
    左世梅. 维生素E与生殖相关疾病的研究进展[J]. 中国现代应用药学, 2020, 37(12): 1532-1536. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYD202012024.htm
    [14]
    SOZEN E, DEMIREL T, OZER N K. Vitamin E: regulatory role in the cardiovascular system[J]. IUBMB Life, 2019, 71(4): 507-515.
    [15]
    刘亚绒, 张峰. 苍附导痰汤加减方联合二甲双胍治疗肥胖型多囊卵巢综合征的效果分析[J]. 山西医药杂志, 2019, 48(22): 2776-2778. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY201922021.htm
    [16]
    赵敏英, 张铭娜, 郭丽娜, 等. 维生素E联合促排卵药物治疗多囊卵巢综合征不孕症的疗效及对氧化应激指标的影响[J]. 河北医药, 2020, 42(3): 357-361. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ202003008.htm
    [17]
    TENUTA M, CARLOMAGNO F, CANGIANO B, et al. Somatotropic-Testicular Axis: a crosstalk between GH/IGF-1 and gonadal hormones during development, transition, and adult age[J]. Andrology, 2021, 9(1): 168-184.
    [18]
    FERRARI U, SCHMIDMAIER R, JUNG T, et al. IGF-1/IGFBP3/ALS deficiency in sarcopenia: low GHBP suggests GH resistance in a subgroup of geriatric patients[J]. J Clin Endocrinol Metab, 2021, 106(4): e1698-e1707.
    [19]
    樊增科, 陈艳林. 来曲唑联合炔雌醇环丙孕酮片对多囊卵巢综合征所致不孕患者血清MCP-1 AMH水平及促排卵情况的影响[J]. 中国妇幼保健, 2021, 36(22): 5252-5254. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202122041.htm
    [20]
    CENA H, CHIOVATO L, NAPPI R E. Obesity, polycystic ovary syndrome, and infertility: a new avenue for GLP-1 receptor agonists[J]. J Clin Endocrinol Metab, 2020, 105(8): e2695-e2709.
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