WANG Haihong, XU Yinan, JIAO Hao. Role of chlorophyll derivative in improving wound healing after hemorrhoidectomy[J]. Journal of Clinical Medicine in Practice, 2024, 28(1): 90-93. DOI: 10.7619/jcmp.20232914
Citation: WANG Haihong, XU Yinan, JIAO Hao. Role of chlorophyll derivative in improving wound healing after hemorrhoidectomy[J]. Journal of Clinical Medicine in Practice, 2024, 28(1): 90-93. DOI: 10.7619/jcmp.20232914

Role of chlorophyll derivative in improving wound healing after hemorrhoidectomy

More Information
  • Received Date: September 12, 2023
  • Revised Date: October 25, 2023
  • Available Online: January 22, 2024
  • Objective 

    To explore the effect of chlorophyll derivative on wound healing after hemorrhoidectomy.

    Methods 

    A total of 124 patients with circular hemorrhoids after procedure for prolapse and hemorrhoids (PPH) were selected and divided into control group and experimental group. The granulation formation time, wound healing time, degree of wound edema and pain before and after treatment, serum biochemical indicators, adverse reactions and complications were compared between two groups.

    Results 

    The granulation formation time and wound healing time in the experimental group were significantly shorter than those in the control group (P < 0.05). After treatment, wound edema score and pain score as well as serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in both groups were significantly lower than those before treatment, and these indexes after treatment in the experimental group were significantly lower than those in the control group (P < 0.05), but the differences of the above indexes before and after treatment in the experimental group were significantly higher than those in the control group (P < 0.05). After treatment, the levels of serum epidermal growth factor (EGF), fibronectin (FN) and basic fibroblast factor (bFGF) in both groups increased significantly, and these indexes after treatment in the experimental group were significantly higher than those in the control group (P < 0.05).

    Conclusion 

    Chlorophyll derivative can promote granulation formation and wound healing after hemorrhoidectomy, and reduce degrees of edema and pain.

  • [1]
    NOMURA E, SUJINO T, HOSOE N, et al. Characteristics of the mucosal surface on scanning electron microscopy in patients with remitting ulcerative colitis[J]. Dig Dis Sci, 2021, 66(9): 3141-3148. doi: 10.1007/s10620-020-06609-4
    [2]
    叶杰阳, 张圣江, 庞苏滨, 等. 黄连膏外敷结合益气活血方对痔疮术后创面愈合的影响[J]. 中华中医药学刊, 2020, 38(2): 226-229.
    [3]
    WEYL A, CHANTALAT E, DANIEL G, et al. Transvaginal minimally invasive approach: an update on safety from an anatomical, anatomopathological and clinical point of view[J]. J Gynecol Obstet Hum Reprod, 2021, 50(1): 101941. doi: 10.1016/j.jogoh.2020.101941
    [4]
    陈苏阳, 蒋燕, 焦胜, 等. 内镜下套扎联合泡沫硬化剂注射治疗Ⅱ~Ⅲ度内痔的疗效及安全性分析[J]. 实用临床医药杂志, 2021, 25(22): 121-125. doi: 10.7619/jcmp.20214123
    [5]
    CARRANCO R C, ZOMER M T, BERG C F, et al. Peritoneal retraction pocket defects and their important relationship with pelvic pain and endometriosis[J]. J Minim Invasive Gynecol, 2021, 28(2): 168-169. doi: 10.1016/j.jmig.2020.05.020
    [6]
    WANG F Y, CKURSHUMOVA W, LIU J, et al. Preventing the release of copper chlorophyllin from crop spray deposits on hydrophobic surfaces[J]. J Colloid Interface Sci, 2021, 582(Pt B): 1149-1157.
    [7]
    韩广辉, 江颖, 曹宁, 等. 苯并吩噁嗪叶绿素衍生物的合成及其光动力抗肿瘤作用研究[J]. 激光杂志, 2022, 43(1): 197-201.
    [8]
    KIM H G, HONG S, CHON T S, et al. Spatial patterning of chlorophyll a and water-quality measurements for determining environmental thresholds for local eutrophication in the Nakdong River Basin[J]. Environ Pollut, 2021, 268(Pt A): 115701.
    [9]
    王海红, 赵志强, 焦浩. 叶绿素衍生物对痔病术后创面愈合的作用和炎性水肿、组织血管生成因子表达的影响[J]. 中国中西医结合消化杂志, 2022, 30(2): 132-137.
    [10]
    金虎. 现代肛肠病学[M]. 北京: 人民军医出版社, 2009: 142-145.
    [11]
    JIN L, YANG H J, QIN K J, et al. Efficacy of modified rubber band ligation in the treatment of grade Ⅲ internal hemorrhoids[J]. Ann Palliat Med, 2021, 10(2): 1191-1197. doi: 10.21037/apm-19-657
    [12]
    KELLER D S, KENNEY B C, HARBAUGH C M, et al. A national evaluation of opioid prescribing and persistent use after ambulatory anorectal surgery[J]. Surgery, 2021, 169(4): 759-766. doi: 10.1016/j.surg.2020.11.006
    [13]
    ITALIAN COLORECTAL ANASTOMOTIC LEAKAGE STUDY GROUP. Risk factors for adverse events after elective colorectal surgery: beware of blood transfusions[J]. Updates Surg, 2020, 72(3): 811-819. doi: 10.1007/s13304-020-00753-2
    [14]
    DRAGANOV P V, AIHARA H, KARASIK M S, et al. Endoscopic submucosal dissection in North America: a large prospective multicenter study[J]. Gastroenterology, 2021, 160(7): 2317-2327, e2. doi: 10.1053/j.gastro.2021.02.036
    [15]
    张珠, 赵雨, 王欣悦, 等. 具有芳并咪唑结构单元的叶绿素类二氢卟吩衍生物的合成[J]. 有机化学, 2021, 41(3): 1177-1186.
    [16]
    SIEGENTHALER F, KNABBEN L, MOHR S, et al. Visualization of endometriosis with laparoscopy and near-infrared optics with indocyanine green[J]. Acta Obstet Gynecol Scand, 2020, 99(5): 591-597. doi: 10.1111/aogs.13803
    [17]
    PATA F, SGRÓ A, FERRARA F, et al. Anatomy, physiology and pathophysiology of haemorrhoids[J]. Rev Recent Clin Trials, 2021, 16(1): 75-80. http://pubmed.ncbi.nlm.nih.gov/32250229/
    [18]
    王猛. 叶绿素衍生物对湿热下注型低位单纯性肛瘘术后创面愈合中Ⅰ型和Ⅲ型胶原蛋白的影响[D]. 张家口: 河北北方学院, 2019.
  • Related Articles

    [1]HU Lele, WEI Yinyu, WANG Jinyan, ZHU Kunliang, LIU Guoying. Relationships of serum angiopoietin-like protein 4 and fibroblast growth factor 23 levels with severity and prognosis of patients with diabetes nephropathy[J]. Journal of Clinical Medicine in Practice, 2024, 28(18): 56-61. DOI: 10.7619/jcmp.20240358
    [2]MA Jing, ZHENG Xisheng, LI Changli, ZHAO Congyuan, DONG Zhaogang. Correlations of serum microRNA-499A-5P, fibroblast growth factor 9 and inflammatory factor with the severity and prognosis of acute lung injury caused by sepsis[J]. Journal of Clinical Medicine in Practice, 2024, 28(8): 55-60. DOI: 10.7619/jcmp.20233049
    [3]XU Ying, XIAO Wenhuan, ZHAO Yilin, YANG Xiang, ZHONG Yunian. Relationship between cognitive function and fibroblast growth factor-2 in patients with schizophrenia and its gender difference[J]. Journal of Clinical Medicine in Practice, 2022, 26(14): 64-69. DOI: 10.7619/jcmp.20220046
    [4]HAN Bei, HAN Junling, CAO Jinghao, YU Yang, GONG Qin. Relation between intact fibroblast growth factor 23 and renal anemia in maintenance hemodialysis patients[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 114-118. DOI: 10.7619/jcmp.20213812
    [5]CAI Liying, LUO Gang. Expression and significance of serum chemokine and fibroblast growth factor 21 in patients with diabetic retinopathy[J]. Journal of Clinical Medicine in Practice, 2021, 25(16): 76-80. DOI: 10.7619/jcmp.20211123
    [6]DU Kaixian, HU Huihui, LI Lin, DONG Yan, GUAN Jing, SONG Chunlan, BAI Yanmin, KONG Lina, JIA Tianming. Value of fibronectin, vascular endothelial growth factor and lactate dehydrogenas levels in cerebrospinal fluid in diagnosing bacterial meningitis and viral encephalitis in children[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 26-30. DOI: 10.7619/jcmp.20210272
    [7]ZOU Xianjun, LI Hai, SUN Liang. Effect of Fufang Jingjie Fumigation Lotion on postoperativewound healing and expression of serum growth factors in patients after perianal abscess surgery[J]. Journal of Clinical Medicine in Practice, 2021, 25(9): 74-77. DOI: 10.7619/jcmp.20201801
    [8]CAI Chuanyun. Effect of modified Xiaochaihu Decoction combined with Jianwei Huayu Decoction on serum growth factor levels in patients with recurrent peptic ulcer[J]. Journal of Clinical Medicine in Practice, 2020, 24(1): 54-57. DOI: 10.7619/jcmp.202001014
    [9]ZHU Chun, HUANG Haidong, WANG Lirui, GUO Zhiyong. Influence of heme oxygenase-1 on expressions of transforming growth factor-β1 and fibronectin in peritoneal mesothelial cells of rats induced by high glucose[J]. Journal of Clinical Medicine in Practice, 2014, (1): 1-4. DOI: 10.7619/jcmp.201401001
    [10]BU Chi-wen, YANG Quan-de, LIU Jing-hong, CHEN Qian. Expressions and significance of pituitary tumor - transforming gene and basic fibroblast growth factor in breast carcinoma[J]. Journal of Clinical Medicine in Practice, 2012, (7): 18-20. DOI: 10.3969/j.issn.1672-2353.2012.07.005
  • Cited by

    Periodical cited type(17)

    1. 徐国亮. 清解补肺汤联合阿奇霉素治疗支气管扩张症的临床疗效. 福建医药杂志. 2024(03): 46-49 .
    2. 计然然,唐燕,匡宁,许翼,汤韦奇. 苏黄止咳胶囊联合福多司坦片治疗支气管扩张的效果. 西北药学杂志. 2024(06): 133-138 .
    3. 叶远航,罗成,柯佳,阚竞,宋远瑛. 支气管扩张症的中医证候特征与中医药治疗研究进展. 中国疗养医学. 2023(02): 139-143 .
    4. 刘中友,郑晓娜. 千金清肺汤联合西药治疗痰热型支气管扩张的临床疗效及对外周血Th17/Treg失衡及相关因子表达的影响. 安徽医药. 2023(04): 835-839 .
    5. 李静,李映,冯品画. 万病回春清肺汤治疗支气管扩张并感染的临床观察及对肺功能的影响. 中国医学创新. 2023(09): 41-45 .
    6. 周同鑫,石静娟,裴昶,曹振华,殷智,钱丽. “支炎一号”方治疗成人痰热壅肺型支气管扩张临床疗效分析. 中外医疗. 2022(02): 103-106 .
    7. 车启富,何丽杰. 桔芩汤联合支气管镜肺泡灌洗术治疗支气管扩张患者的临床效果. 国际医药卫生导报. 2022(06): 858-862 .
    8. 胡文海,叶欣,汤国敏. 桔芩汤治疗支气管扩张患者对临床证候、肺通气功能的影响. 中医临床研究. 2022(02): 44-47 .
    9. 徐瑜俊. 云南白药胶囊与酚妥拉明联合用药方案治疗支气管扩张咯血的临床效果. 现代医学与健康研究电子杂志. 2022(09): 92-94 .
    10. 钟云青,胡春明,黄丽敏. 支气管扩张症急性加重痰热蕴肺证的中医治疗进展. 医学综述. 2022(15): 3057-3061 .
    11. 周亮亮,任宏伟,曹国芸,李梦云,李芳,刘宁,王玉彬. 清肺化痰解毒汤联合头孢哌酮/舒巴坦治疗支气管扩张症伴感染(痰热壅肺证)的临床研究. 中国中医急症. 2022(11): 1941-1944 .
    12. 孙锦贤,余静珠,屠春林,胡建荣,朱丽萍. 加味桔芩汤对支气管扩张痰热壅肺证抑郁焦虑、生命质量、炎症标记物及肺功能的疗效观察. 吉林中医药. 2022(12): 1418-1421 .
    13. 谭道富,谭艳华,田朝晖,向建军. 山药化痰汤治疗对气阴两虚痰热壅肺型老年重症肺炎患者中医症状积分和肺功能的影响. 四川中医. 2022(11): 99-102 .
    14. 谢文,黄青松. 中医药治疗支气管扩张症的药理机制研究进展. 中医药导报. 2021(08): 123-127 .
    15. 田艳艳,严廷巍,李景莉,马兰萍. 清肺消痈方联合盐酸氨溴索治疗支气管扩张症的效果及对患者MCP-1、MMP-9的影响. 四川中医. 2021(12): 84-87 .
    16. 赵芳,刘振国,常瑛,葛莉,李芳. 肺热清颗粒联用糖皮质激素对小儿支气管哮喘氧化/抗氧化失衡的影响. 湖南师范大学学报(医学版). 2021(06): 171-174 .
    17. 聂光荣. 百合固金汤联合复方穿心莲治疗阴虚肺热型支气管扩张的临床疗效. 临床合理用药杂志. 2020(36): 131-133 .

    Other cited types(4)

Catalog

    Article views (142) PDF downloads (8) Cited by(21)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return